Plasminogen Receptors
نویسندگان
چکیده
1Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, SP30-3020, La Jolla, CA 92037, USA 2Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA 3Department of Biochemistry and Molecular Biology, Sir Charles Tupper Medical Building, Dalhousie University, 5850 College Street, Halifax, NS, Canada B3H 4R2 4Department of Medicine, University of California San Diego and Veterans Administration San Diego Healthcare System, San Diego, CA 92093, USA
منابع مشابه
So Many Plasminogen Receptors: Why?
Plasminogen and plasmin tether to cell surfaces through ubiquitously expressed and structurally quite dissimilar family of proteins, as well as some nonproteins, that are collectively referred to as plasminogen receptors. Of the more than one dozen plasminogen receptors that have been identified, many have been shown to facilitate plasminogen activation to plasmin and to protect bound plasmin f...
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OBJECTIVE Plasminogen system plays a crucial role in physiological and pathological events related to tissue regeneration, wound healing, immune response, angiogenesis, invasion and metastasis. It gets activated when plasminogen associates with its cell surface receptors. Latest information on some of the well-explored plasminogen receptors such as annexin II-S100A10, cytokeratin 8, α-enolase, ...
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Multiple species of bacteria are able to sequester the host zymogen plasminogen to the cell surface. Once localised to the bacterial surface, plasminogen can act as a cofactor in adhesion, or, following activation to plasmin, provide a source of potent proteolytic activity. Numerous bacterial plasminogen receptors have been identified, and the mechanisms by which they interact with plasminogen ...
متن کاملPlasminogen receptors: the sine qua non of cell surface plasminogen activation.
Localization of plasminogen and plasminogen activators on cell surfaces promotes plasminogen activation and serves to arm cells with the broad spectrum proteolytic activity of plasmin. Cell surface proteolysis by plasmin is an essential feature of physiological and pathological processes requiring extracellular matrix degradation for cell migration including macrophage recruitment during the in...
متن کامل[Frontiers in Bioscience 8, s294-304, May 1, 2003] 294 PLASMINOGEN BINDING AND CANCER: PROMISES AND PITFALLS
1. Abstract 2. Introduction 3. Plasminogen conformation and activation: structure function relationships 4. Plasminogen binding to the cell surface 5. Mammalian cell surface plasminogen receptors 5.1. Multiple, distinct proteins may act as plasminogen receptors 5.2. A bona-fide receptor must be shown to be at the cell-surface 6. Regulation of plasminogen binding capacity is linked to uPAR-bound...
متن کاملRegulation of plasminogen receptor expression on human monocytes and monocytoid cell lines
The capacity of human monocytoid cell lines and peripheral blood monocytes to modulate their expression of plasminogen receptors has been assessed. After PMA stimulation, THP-1 or U937 monocytoid cells were separated into adherent and nonadherent populations. Plasminogen bound to adherent cells with similar capacity and affinity as to nonstimulated cells. In contrast, the nonadherent cells boun...
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ورودعنوان ژورنال:
دوره 2012 شماره
صفحات -
تاریخ انتشار 2012